I experienced the same issue trying to run the newly installed Reader app (v1.1.05.13310). In my case it turned out to be that: I run my Mac with a case-sensitive filesystem, and the binary is looking for the framework library with a slightly different name than what it installed. It seems to be looking for this:
/Applications/Reader.app/Contents/Frameworks/QtWebKit.framework/Versions/4/QtWebKit
but it actually installed this:
<same path>/QtWebkit
Note final lower-case "k". Simply renaming the framework file as QtWebKit solved the problem for me.
This is clearly just a filename case naming bug in the build, they didn't do testing and QA on a Mac with case-sensitive filesystem. If I can figure out how to file a bug report with Sony, I will do so...
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