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I don't see how a problem with an AV can be blamed on calibre.
However trying to blame a free an opensource project for it's lack of intensely use-case specific issue, without even mentioning the vendor directly, will help absolutely no one.
Considering you are also using a fresh username and no link to the supposed support ticket, there is no way to even check for previous posts on this topic; Not only cowardly, but once again completely unhelpful.
I hope that you have at the very least reported the issue to the AV vendor, as allowing it to thrash drives is not really an ideal behavior, and having compatibility with pretty ordinary desktop software is not a really good showing.
Lastly calibre running on a normal Windows install does not really have the low level access required to damage your partitions, however an AV does. Not even mentioning possible hardware issues — Where should the blame lie?
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