Second for the Kobo Touch. I really like mine, and you can move the page turn zone around to make it more comfortable for left-hander's, as Terminator described.
With it set up for left-handed forward page turns, you could quite easily just hold it in your left hand. If you set it up for right-handed, with most of the screen take up for the forward page turn going to the right edge, you could access both forward and back page turns with your left hand only.
Jaden, from within a book, it only takes me 3 taps to acess the page turn zone settings. Center screen, settings, advanced, there you are.
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