You can try building Python, PyQt and PyOnyx yourself following this guide:
https://wiki.mobileread.com/wiki/Boox...th_Scratchbox2
I had no time to continue work on PyOnyx recently, so I can only answer pkbo's question no. 2: Executing the script from the menu doesn't change anything. I'm pretty sure now, it's not a "focus" problem, but something more complicated :-/