I' sorry to tell that the problem popped up again. It are the various windows updates that seem to cause the problem. After installation of "Windowsserver2003.WindowsXP-KB924961-SP2-X64-ENU.exe" and a restart of computer Calibre runs fine. But later on Windows XP Update collects an update from the site of Microsoft and after this update has been installed and the compuer had been restarted, the old problem occurs again. Bad bad bad.
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