I mainly used my DX for A4 sized PDFs from work. (Similar to US letter format.) I usually have to read several hundred new pages per week, and the DX was a far better option than reading on the laptop or printing it all out.
Since I bought an iPad, however, almost all my PDF reading is done on that. It's easier to keep in sync (Goodreader with Dropbox sync folder vs. manual copy via USB), has better search capabilities and is faster if you just want to quickly scan the pages instead of reading them in depth.
The DX has superior battery life, of course, but charging the iPad overnight works perfectly well, so it doesn't make much of a difference in practice.
I definitely do prefer e-Ink for personal reading (novels, etc.), but in a smaller form factor, so I usually use my Kindle 3 for that – although my girlfriend is starting to hog it a lot these days, so I might need to drag out the DX again after all. ;-)
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