What is the spec of your machine, particularly in terms of RAM? I use calibre2opds with my library on a NAS and about 16k books with an average of about 4 formats per book. My metadata.db file is over 70MB. Calibre2Opds tends to peak at around 350MB RAM usage when handling this.
In practise I would have thought that 512MB RAM was a minimum for both Calibre and Calibre2Opds, and 1GB was more realistic. This is very low for most modern machines which tend to have considerably more RAM.
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