Paul, as you can see on many threads here at MR, choice of formats, companies, and devices can rise to the level of religious devotion for some.
Two of the most important topics you may want to consider are your preferences for an open or proprietary file format, and how comfortable you are with leaving your e library with a single corporation or entity for use on only their hardware.
Food for thought: In the early days of the web, Netscape was a major player and a multi-billion dollar company. Beginning to end, as an independent entity, Netscape lasted four years.
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