All fiction is 'made up.' It all must be internally consistent. For something to be Science Fiction (instead of Fantasy) only requires a reasonable explanation of the real-world basis for the science in a manner that the reader can accept. Fantasy does not require the explanation so much but still has to be consistent and the reader must buy in with a willing disbelief and acceptance of trust in the author. There is much overlap and a full spectrum of stories from one to the other as well as into mainstream, horror, etc. etc. etc.
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