It could be a faulty cable. I had a cable that when I plugged in a 505, it would allow the computer to see it and then stop seeing it and back and forth. it was the cable.
From what I have read on MR, one thing to try is using a different USB port. Also, if it's a USB hub you have the 650 plugged into, that could possibly be an issue.
Also if you have another computer you could try plugging the 650 into that and see what happens.
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