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I have made many PDF ebooks (none posted here) for the Sony Reader. In general, there is a very slight delay when using embedded fonts rather than using the built in fonts. (Yes, PDFs on the Sony default to using Dutch and Swiss as the base fonts.) I do not know how BookDesigner or calibre embed fonts; but, Adobe Acrobat embeds only the glyphs of characters used in the PDF so it is very economical (from both size and speed perspective) to use other fonts for accent purposes. Additionally, the rendering seems to bring in only the glyphs required for the current page and appears to be able to reuse any glyphs that appeared on the prior page.
I hope this helps.
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