One thing to bear in mind is that Amazon's KF8 format is now supported by Kindle Fire, Kindle for Mac and Kindle for PC. Firmware upgrades for "current" eInk Kindles should be along soon.
KF8 has formatting options about the same as ePub. I know that calibre can read KF8 files, but I don't know if it can create them yet, but Amazon do provide KindleGen that can take in an ePub and produce a join Mobi/KF8 files for upload to Amazon.
Currently, I'd recommend creating an ePub, but taking care that the formatting translates well both to original mobi and KF8. It might need to use of a Amazon-specific CSS file.
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