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Including only the required characters would certainly help a lot with the size of the font. But adapting a font like this is beyond the ability of most people, so if it's not done by the ebook creation tools like Sigil/Calibre, it's simply not done.
But I'd expect most readers to support special characters for European character sets out of the box. Even English books have them sometimes if it's writing names the way they're supposed to be written...
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