If you have your images such that there will be only one per screen in the final version you should be able to build a reasonably successful epub.
Centering: You can center the images left to right, but since epub has no concept of "page" there is no true centering top to bottom. I find it easier to use an epub editing tool (I use Sigil, which has great support in its own fourm here at MR) to tweak thing in an epub. You can do some things with calibre, either through the "extra CSS" field in the conversion dialog and calibre can "crack" the epub so you can manually edit the CSS and (x)HTML files via its Tweak ePub function.
Clipped images: This will be an issue with any full page image based ebook. If your images have the same aspect ratio as the device being used it's not hard to accomplish a proper fit. If they don't match its more difficult. If you create 3:4 ratio images (e.g. 600 x 800 pixels) and set the width of the images to "100%" in the <img> tag in the (x)HTML file they will fill the screen on most ereaders with 3:4 screens (eInk Kindles & Nooks) and will leave a blank area, generally at the bottom, on screens with a 3:5 aspect ratio (Kindle Fire, Nook Color, Nook Tablet, ...). To do this you may have to edit the ePub manually to get a line like:
<img src="../Images/page01.jpg" width="100%" />
Also, an all image book is not going to play well with any change in reader orientation. Vertical images will work fine when the reader is used in its normal vertical orientation. Horizontal images will be problematic. If you turn them in your image editor so that they are presented as "verticals" they will read fine with the reader turned horizontal, but only if the reader doesn't have an automatic orientation function enabled.