I had multiple issues with the ebuild. For one thing it's only masked for the AMD64 platform (I'm using x86). The dependencies were also quite the headache, and they didn't pull in everything that was needed. I do see that there's a new one since I last tried (0.4.64), so just to humor you, I tried it again....
Traceback (most recent call last):
File "__init__.py", line 16, in <module>
from calibre.translations.pygettext import main as pygettext
ImportError: No module named calibre.translations.pygettext
Which means it's not even possible to emerge it. I do see the pictureflow library being built.
I realize that's an issue to pass to the ebuild maintainer, but I honestly start to wonder if there's too much bloat and dependencies on external libraries. I do think it's a great product, I just see a lot of "hey, I added XXX feature", instead of streamlining the code base. Platform independence is hard, but I am not convinced Python is the way to get there.
The last paragraph is just an opinion and naturally perfectly acceptable to ignore.