To me it sounds like the K3 / Kindle Keyboard is your best bet. It has text to speech, page turn buttons and 3G, plus it's easy to buy books on. It can probably play audio-books too. It's only downer is the keyboard and lack of touch. I'm a Sony fan-boy, so my opinion is objective on this.
You're friend is lucky to have someone who is going to the trouble for her. Compassion is in surprisingly short supply.
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