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For Kindle there are ready to use products for persons with disabilities, such as PageBot; it supports various kinds of buttons (very large easy to press ones or even mouth controlled).
Only downside to such a solution is the price... the pagebot does not modify kindle hardware but rather it's a mount with a mechanic that presses the button on the kinde for you when you press the pagebots buttons. Other projects such as Frankenkindle hook such buttons up directly with the Kindle hardware itself which should be a less complicated solution - but requires some electronics knowledge
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