Metadata are obviously not *completely* neglected by publishers, as marketplaces would have a hard time presenting their customers with content without the <creator> and <title> tags being filled in.
It seems that there might be chances for eBook publishers who DO take advantage of the complete ePub2 metadata possibilities, ie <subject>, <description>. This of course presumes that we as publishers have any idea of how the different marketplaces process these tags, or how this may affect discoverability and ultimately sales.
I for one don't know these things, but I'm hoping some of the more seasoned members here do, and don't mind sharing some of their "trade secrets"