I've kept my computer running 24/7 for 3.5 years so far and it still runs like a champ. Occasionally I will let it go to sleep mode overnight, but those are very rare occurrences.
The main thing I do is have my monitors turn off after 10 minutes rather than use a screensaver. That seems to save a ton of energy / heat, since I'm using dual 24 inch monitors.
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