I've read a few books on a laptop. They were fiction books, only available in pdf format and Adobe reader was pretty much the only option available to me at that time. The laptop is a bit clunky for use as a reader all the time, but passable for something I really wanted to read.
More recently, I've read a little on a Netbook using the Nook and Kindle for PC applications. That actually worked out OK on a table at work during breaks. I'd go back to the netbook for reading if I didn't have more portable options available now.
Backlit LCD screens don't bother me for reading, depending on the lighting, I even prefer them in some situations.
Desktop computer though? I'll pass on using one for reading, I just can't get comfortable enough.
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