One thought that I have on the science in science fiction is that you should depart from the science when you must in order to tell the story, but you should understand that you are departing from science. That means you should know the science - not necessarily the latest bleeding edge science, but the really basic stuff.
Too often, they depart from science not because the story requires it, but because they don't understand what the science is. Often, including the real science would have given a better story.
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