Well... even today the pilot (human) limits fighter jet performance. In the far future it is hard to imagine battles would not be fought with autonomous drones if any manuevering caused an advantage.
Given a similar level of technology and power source, you design a human ship with inertial dampers and I'll design an autonomous drone ship. Your ship will consume too much mass and power while still being less nimble. I'll have more mass for engines, shields/armor, and weapons. Then again, there was that Star Trek TOS episode with the "suicide mission" ship that attacked an Enterprise full of diplomats...
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