[obsessed2]

I'm running straight Ermine 2.2 on 2 PEs and an EE and have never had any serious response issues that weren't corrected by a shutdown and restart like Filark said. Sometimes the e-ink side can become somewhat unresponsive when you attempt to do a search in a large book and then return to the home screen of the LCD. Even when you reopen the Library the Search won't pop back up but continues to run in the background. It almost sounds like your reader is stuck in Search mode.