In your MobileRead User Control Panel, (User CP link in blue bar), Go to Settings & Options/Edit Options and set the "Default Thread Subscription Mode" to "No email notification".
That will stop future emails from new threads that you comment on. For the existing subscriptions, go to Subscribed Threads/List Subscriptions, click in the check box in the header of the list (on the right hand side) to select all your subscriptions, then scroll to the bottom, to the pop-up menu marked "Seelected Threads:". Set the pop-up to "No email notification" and click on the Go button.
You should now receive no more email messages about threads you've commented in.
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