I found a workaround for the occasional-bad-JPEG problem:
1. Save the source document in a format that files the images in an accessible directory (e.g. HTML). (Obviously, you can skip this if you're converting to filtered-HTML anyway during ePub creation.)
2. Run the directory through a batch picture resizer (I use Picture Resizer --
http://www.rw-designer.com/picture-resize), set to output 100% original size at an image quality no worse than the pictures are already. (Alternately, cranking down the quality a bit, within acceptable limits, can be done if you want to shrink your final filesize a bit.) Replace the images in the HTML directory with the output (Picture Resizer can be set to simply overwrite them directly).
3. Re-save in your preferred format (or go ahead to building the ePub from the HTML version).
As I said, it's a workaround; hopefully whatever problem is causing Mantano to choke on the occasion JPEG will be fixed at some point.