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1) Battery life: e-ink based reader. Not even a fair comparison there.
2) Eyes: the discussion is still out there. Some will swear to e-ink, others to LCD and a third group to both.
The problem with backlit devices is that people often leave the backlight to 100% and use a white background with black letters. Which will cause a headache within the minute.
Advantages of e-ink (leaving out battery life): stable, no refresh. In general (especially the Pearl screens) decent to good contrast.
Disadvantage: if there's not a lot of light (you might just be able to read a normal paper book), the e-ink will be harder to read and you'll need extra light. Some people don't like the refresh flash when paging (though most won't even notice it anymore after the first time...)
In-the-middle: not really handy if you also want to use the device to do some internet stuff. It will work, mostly, but can be a pain. I leave this in the middle as you might or might not want to be able to do that. And it's only gray-scale atm (again, not interesting if you only read novels with it)
Advantages of LCD: backlit, which means you can also use it in bad light conditions. If you get a decent tablet, you'll get good to great contrast.
Disadvantage (not counting battery life): sometimes the backlight can be too much, especially if you don't turn it down the darker it get.
In-the-middle: A tablet is more a multi-purpose device. Internet, movie, social media (shudder), pictures, etc. Also, reading comic books will most often be more pleasurable, due to the colour screens.
Personally, I have both. I read on my Sony or BBMini (both e-ink) during the day, mostly in summer (not enough day in winter...) and on my Flyer at night and in winter. And during our holiday this summer (3 weeks trekking with only a car and a tent), an e-ink device with that long battery life was very handy!
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