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I have arthritis in my hands, and I prefer the Kindle. The Sony page-turn buttons are small and require a fair amount of pressure, which equates to cramped hands in fairly short order in my experience.
Kindle has that button up the side, and if you keep it in its cover (I use the M-Edge cover) it's quite easy to hold and whap the page-turn button while being able to move your hands around to avoid cramping.
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