Harry's excellent advice notwithstanding:
There
are some subtle differences between how MOBIs render on a Kindle device and how they render on the various Kindle for * apps (and
between the apps) that can't really be taken into consideration (with a single source document anyway), but paragraph and header spacing shouldn't be one of those things if you follow Harry's advice.
Quote:
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And is there likely to be variations between different models of real Kindles too?
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Maybe with the 1st generation Kindles, but things seem to render fairly consistently on the other devices (though I have no experience with the latest eink generation—and the KFire would probably fall under the "app" category).