Nice to see how obviously serious you are about this.
I think the form factor is crucial. I can squeeze my Kindle into my back pocket, but my Sony 350 was soo much smoother in that respect. A buzzword to aim for would be "pocketability", maybe some sort of handle on the backside that lets you hold it in one hand and turn pages with your thumb. Reader in backpocket and keyboard in front. The reason I suggested BT is that it frees the user from carrying a cable. Keep the user in focus and you won't go wrong.
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