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I also use Kaspersky and after reading this thread, I added calibre.exe to the excluded and trusted lists. Wow... what used to take forever to load now takes just a few seconds to fully load Calibre (and I mean literally 2-3 seconds now). I still let Kaspersky scan any net activity just in case I manage to get a virus that plants itself in the Calibre directory, and that's not slowing it down at all.
So there's a good and easy workaround for it.
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