I find it tough to go to sleep if I'm looking at an LCD screen at night, but not so if I'm reading from an E-ink display. I'm far too used to LCD displays over the years to let it give me a headache unless I'm staring at it all day long, but I do have friends who get headaches from looking at an LCD screen for more than a couple of hours.
LCD screens do affect humans in a way that is different to e-ink, no denying it.
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