I've used the Clie and Palms for many years but I had to give it up because I have really bad vision (If you look up the phrase "Blind as a bat" you'll see my picture.) and the small backlit LCD screens were giving my ferocious headaches. Personally I find the contrast on the eInk screens as good as that in a paperback novel. It's not as good as a backlit LCD but the lack of eyestrain makes up for any deficiencies in contrast.
With a small screen such as those on a PDA you will do a lot more page turning. The touchscreen makes it fairly easy but I found the constant page turning somewhat disruptive. Larger screen, fewer page turns.
If you decide to try the Kindle, Amazon has a generous return policy. You are not locked in to purchasing only Amazon content, any MOBI ebook without DRM easily transfers to the Kindle.
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