I tend to be pretty sensitive to that which causes me stress, and if I am reading for a long duration, LCD definitely adds to the eye strain. It doesn't help that in many cases, I am reading under fluorescent lights which only adds to the strain. After a long session of reading, LCD makes me feel more tired and normally, I will have a slight headache. But if I am reading 15 minutes here and there, it doesn't really bother me. E-Ink, esp the new B&N Nook, is best for me. I spent 6 to 7 hours reading under fluorescent with no problem the other day on it.
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