No one needs to bother building a package on OS X except Kovid, or maybe someone who needs to modify one of Calibre's very few C++ components.
The typical Calibre dev is just working on the python code, and in that case using the CALIBRE_DEVELOP_FROM variable is with calibre-debug is all that's required (follow the steps in Dwanthny's link) - that tells Calibre to use your source directory instead of it's bundled python code.
The only other valid reason I could think of for trying to get the whole build system working is if you were trying to fork Calibre. Maybe if you explain to us why you feel it necessary to build the whole package we could provide some better direction.
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