Home and power aren't unresponsive, they just have multiple functions. Pushing home once takes you back to the last home screen you were on; pushing it again takes you to your main home screen; long-pressing it launches Recent Apps (I would suggest tracking down Recent Plus on the market, which adds a brightness slider and/or volume slider to that window). With power, pushing it once turns the screen on or off, while long-pressing it launches the power menu, and continuing to hold it forces a hard shut-down.
There are touch response issues toward the edges of the screen, though it varies from app to app, with the Nook for Android app being one of the worst (at least older versions--haven't opened it lately).
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