I havent actually tried, but from experience irssi does not deal very well with terminal's which dont report column count where it expects them to be, which makes it a bit iffy with some windows systems and such (i,e where you might resize it).
That said, I'd have a go at trying to build weechat, I've found it rather robust in the past, it's also a whole lot easier to configure for use on different devices - as well as just being a whole lot better than irssi on the whole.
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