Plenty of epubs that show up perfectly in Sigil and Calibre display only a "?" when displayed by the reader, particularly those with letter such as "ō" or "ž". I have also made the experience that often the epub doesn't show the cover while it is shown perfectly once converted into lrf.
Maybe this is somehow the fault of the publishers but I don't see it as my job to rework epubs just to have them displayed properly by the reader.
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