In a word: nope.
The displays of the current e-ink devices are simply too small for hindrance free PDF viewing, unless the "pages" in the PDF files are sized to match the device's display size, that is.
The iRex iLiad is the least bothersome because it has a bigger display (8" diagonal), and there are some 9" displays that are supposed to be coming out over the summer (breath holding is not recommended!). Those should be better still, but most likely won't really be big enough either for most purposes.
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