I love the size of the 350 and don't find the screen is too small for me at all. My eyes are pretty bad too and in dimmer light I even read at medium font quite often and I'm still not bothered by the screen size. So you have a few less lines of text per page meaning a few more page flips... it takes just the slightest thumb movement on the screen to turn the page so I don't even realize when I'm doing it, it's not an issue at all.
Originally I thought I wanted the 6" screen, but they were hard to find at the time. Then the 350 went on sale and I bought it thinking I was going to end up returning it for the 650. Instead I fell in love with the size of it, it's very comfortable to hold for long periods of time as well. I don't leave home without it.
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