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Do you do a lot of printing? If you do, it's a lot easier from a computer than a tablet.
Do you have unusual hardware that you absolutely have to have that only communicates a computer? "Unusual hardware" could be anything, but in my case I'm thinking about medical devices that upload data to the computer for analysis. Tablet support for unusual hardware may not be as robust as it is with computers.
Do you have specific software that you just can't live without that only runs on a computer? Again, this could be anything, just make sure you look before you leap. In my case, the killer app is Microsoft Access. I'd love to consolidate all my hardware and just use a tablet, but without Access (and communication with medical devices) I'm stuck not only with computers, but PCs.
YMMV
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