I use both Second Copy to create a local backup of files to an external hard drive, and Carbonite to create an offsite backup. I've been very happy with both. Both have saved me from disaster and stupidity.
For online services, I'd recommend that you select a service that encrypts your data before it is sent up to their server. This way if they're hacked, you data is still encrypted, and if a court issues a subpoena for your information, all they get is an encrypted file.
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