You also need to adjust the line-height unless you want the first line to have extra space under it. The default is for everything to have a line-height of 1.2 (without any unit, which is important here). You need to change that to 1.2em in the body or p tags so that every line has a line-height that's calculated off the base font-size, rather than allowing each line to calculate its line-height independently.
Alternatively, you can set the line-height in your span to be equal to (line-height of body text)/(font-size in span). So if your first capital is 2.5 em and the body uses a line-height of 1.2, the span needs a line-height of 0.48.
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