If you leave the metadata exactly as it was during import then Calibre won't make any changes during the transfer to the reader.
As far as covers goes, it's rare that Calibre actually successfully changes to a configured cover during the transfer, as it will only replace the cover if a semantically 'correct' cover exists in the ePub. Most commercial ePubs do not have semantically correct covers, they just have a image as part of the first flow - in these cases Calibre would only update the ePubs textual metadata if it's been changed during the transfer.
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