I've only really had to create two separate formats for both print and digital.
My discovery at least with the Sony and Nook1 (gave the kindle to the ex as a parting gift) is that if you use "left justify" and 10 or 12 pt Optima, nothing else really matters and the formats have thus far been acceptable at best. I test on S and M font sizes, to try and get all different sizes would be an exercise in futility. Then again, I haven't received any complaints because I haven't sold anything yet. =)
As a whole though, I only physically create two formats in Scrivener, my draft format and the "_format" suffixed novel. That one has all my little pretty ponies and full justification.
I find that with Scrivener 2.0, using the default "Compile to..." Kindle, ePub, and Doc formats produce really good results.
Unless you export Doc to Pages, then you're in a whole other world of hurt.
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