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I have used tweak epub to change the stylesheet css.
I also use it to get rid of an ugly cover or other odss and ends which aren't removed/modified on conversion.
I use the preview epub function to see if it has worked. Usually it does.
If you are experimenting perhaps modify the stylesheet.css (sometimes stylesheet1.css) and change all of the font-style: settings to bold or italic and look at the preview.
While I am sure it can be done, it may not be the best way to edit the text in a file
Helen
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