The problem with technical books is that they often have diagrams, charts, figures, and pictures that don't display well on the average 6" screen. In addition, PDFs often have page headers and footers, with such things as page number, book or journal title, and author. When the reader tries to reflow this sort of document, the header and footer stuff often ends up buried in the text. The best option for a "native" display, where the pages look like they do on a computer screen is a larger reader. The Sony 950, Kindle DX, and Pocket 902 all come to mind.
The ePub format is designed to reflow well on any screen size, so that often helps with the header and footer problems. However, there's only so much space on a 6" screen to display information, so the charts and diagrams would still be a potential issue.
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