See: America's Most Literate Cities 201, a study by Central Connecticut State University (
http://www.ccsu.edu/page.cfm?p=8227)
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Drawing from a variety of available data resources, the America’s Most Literate Cities study ranks the largest cities (population 250,000 and above) in the United States. This study focuses on six key indicators of literacy: newspaper circulation, number of bookstores, library resources, periodical publishing resources, educational attainment, and Internet resources.
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St. Louis, btw, ranks in the top 10 overall, but is #46 in educational attainment. It is in a tie with Portland Oregon in the overall rankings. Portland ranks 4th in educational attainment.