To summarize many threads...
You want to take annotations? Then the SONY PRS950 is the best option - thanks to the touchscreen.
You want to just read? Amazon DX, thanks to the largest screen.
My advice? Get an iPad. The backlit screen does tire your eyes, but it's still the best handling of PDFs. Some people would recommend other (Android based?) tablets - but I still find the iPad to be the best option, thanks to some very neat PDF-specific apps (such as iAnnotate).
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