^For digital things you want the device to handle most of the layout freeform. Trying to force where it is will cause problems when a user tries to read the book in a larger font than the author thought of. A book from jpeg images is going to annoy a lot of people.
I do agree with that symbols are a problem. Right now certain books just don't translate as well into e-reader formats. Then again, there are some types of books that I wouldn't buy in a e-format yet. Yet. I'm hopeful that won't always be the case, but so far it is.
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