Yes, it works fine, though if your Mac is newer and runs natively in 64-bit mode you will most likely need to run it in 32-bit to get it to work properly. This has been my experience, and has been reported by other Mac users here as well.
Alternately, just use Calibre. You can use Calibre to store and upload DRMd books, you just can't view/convert them with Calibre.
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